Thiamine-Responsive Congenital Lactic Acidosis: Clinical and Biochemical Studies
نویسندگان
چکیده
منابع مشابه
Severe lactic acidosis reversed by thiamine within 24 hours
iamine is a water-soluble vitamin that plays a pivotal role in carbohydrate metabolism. In acute defi ciency, pyruvate accumulates and is metabolized to lactate, and chronic defi ciency may cause polyneuropathy and Wernicke encephalopathy. Classic symptoms include mental status change, ophthalmoplegia, and ataxia but are present in only a few patients [1]. Critically ill patients are prone to t...
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The term congenital lactic acidosis (CLA) refers to a group of inborn errors of mitochondrial metabolism variably characterised by progressive neuromuscular deterioration and accumulation of lactate and hydrogen ions in blood, urine and/or cerebrospinal fluid, frequently resulting in early death. The incidence and prevalence of CLA are unknown, although it has been estimated that there are appr...
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This report describes a case of d-lactic acidosis observed by the authors and then reviews all case reports of d-lactic acidosis in the literature in order to define its clinical and biochemical features and pathogenetic mechanisms. The report also reviews the literature on metabolism of d-lactic acid in humans. The clinical presentation of d-lactic acidosis is characterized by episodes of ence...
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Ruminal lactic acidosis is a condition that arises in ruminants due to the ingestion of excess quantities of easily digestible grains leading to diarrhea, anorexia and physiological derangements which can be fatal in severe cases. A clinical case of cow with history of rice flour ingestion showing signs of acute ruminal lactic acidosis was managed. The pH of ruminal fluid was 5.1. The number of...
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ژورنال
عنوان ژورنال: Pediatric Neurology
سال: 2005
ISSN: 0887-8994
DOI: 10.1016/j.pediatrneurol.2005.02.007